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In Middletown, at 11:14 PM, two cars accidents happen at the same time, affecting the lives of five different groups of people. A drunken driver hits a man in a lonely road near a bridge; three young men hits a woman with a van, one of the passenger has a severed penis while another man on the road shoots them; a young man robs a convenience store, with the support of the clerk; a man finds a body in a cemetery and gets rid off it; and a young woman pretending to be pregnant tries to raise money for an abortion. All of these characters and their fates are very connected.

A modern day look at America’s war on drugs told through four separate stories that are connected in one way or another. A conservative politician who’s just been appointed as the US drug czar learns that his daughter is a drug addict. A trophy wife struggles to save her husband’s drug business, while two DEA agents protect a witness with inside knowledge of the spouse’s business. In Mexico, a corrupt, yet dedicated cop struggles with his conscience when he learns that his new boss may not be the anti-drug official he made himself out to be.

This is the story of three gentle persons: Paul Rivers (Penn) an ailing mathematician lovelessly married to an English emigré (Gainsbourg), Christina Peck, an upper-middle-class suburban housewife, happily married and mother of two little girls, and Jack Jordan (Del Toro), an ex-convict who has found in his Christian faith the strength to raise a family. They will be brought together by a terrible accident that will change their lives. By the final frame, none of them will be the same as they will learn harsh truths about love, faith, courage, desire and guilt, and how chance can change our worlds irretrievably, forever.

A missile disappears in Iran, but the CIA has other problems: the heir to an Emirate gives an oil contract to China, cutting out a US company that promptly fires its immigrant workers and merges with a small firm that has landed a Kazakhstani oil contract. The Department of Justice suspects bribery, and the oil company’s law firm finds a scapegoat. The CIA also needs one when its plot to kill the Emir-apparent fails. Agent Bob Barnes, the fall guy, sorts out the double cross. An American economist parlays the death of his son into a contract to advise the sheik the CIA wants dead. The jobless Pakistanis join a fundamentalist group. All roads start and end in the oil fields.

Richard and Susan are a couple from San Diego, California who are vacationing in Morocco while their two children are at home with their Mexican housekeeper, Amelia. A rifle finds its way into the hands of a local herdsman’s young sons, who recklessly take a shot at a tour bus and hit Susan in the shoulder, causing her severe injury. The distraught Richard calls home to tell Amelia of the situation, who shortly departs for Mexico to attend her son’s wedding, with Richard and Susan’s children in tow. Disaster thus multiplies, with the situation in Morocco ascribed to terrorists in the media, while Amelia meets with trouble at the Mexican border when she attempts to return to San Diego with Richard and Susan’s children. Meanwhile, in Tokyo, a widower tied to the rifle in question, a complex shift of ownership to which the audience is privy, attempts to deal with the memories of his recently deceased wife and his strained relationship with his deaf teenage daughter.

Jules Winnfield and Vincent Vega are two hitmen who are out to retrieve a suitcase stolen from their employer, mob boss Marsellus Wallace. Wallace has also asked Vincent to take his wife Mia out a few days later when Wallace himself will be out of town. Butch Coolidge is an aging boxer who is paid by Wallace to lose his next fight. The lives of these seemingly unrelated people are woven together comprising of a series of funny, bizarre and uncalled-for incidents.

“Sin City” is Four stories inter-weaved telling tales of corruption in Basin City. The First Story (The Customer is always right)is short, and is based on the depression of women that they need to pay a man to feel loved when they commit suicide. The Next Story is Part 1 of “That Yellow Bastard” starring Bruce Willis as a cop who needs to save a young girl from being raped. The Third Story (The Hard Goodbye) features Mickey Rourke and his revenge on a heartless killer who murdered his one-night stand. The fourth story (The Big, Fat Kill) stars Clive Owen as a man who must dispatch of a cop’s body, but it will be a tough ride to do it. Following that are two conclusions to Sin City, the ending of “That Yellow Bastard” which is set 8 years later, and a short story that ends Sin City.