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A descent into Hell is triggered when “Ex-Lord” Donald Brocklebank finds that he must leave Longleigh House for London to find a way to pay for the medical treatments for his wife Nancy. Alone, his over-protected, delusional, adult son, James, fancies himself in charge of the manor house with his terminally ill mother, and barricades the two of them into the house for a series of ever more panicked home treatments, mistakenly protecting her from the arrival of Nurse Mary and any outside help.

After a violent storm attacks a town in Maine, an approaching cloud of mist appears the next morning. As the mist quickly envelops the area, a group of people get trapped in a local grocery store -among them, artist David Drayton and his five-year-old son. The people soon discover that within the mist lives numerous species of horrific, unworldly creatures that entered through an inter-dimensional rift, which may or may not have been caused by a nearby military base. As the world around them manifests into a literal hell-on-earth, the horrified citizens try desperately to survive this apocalyptic disaster.

Malcom Crowe is a child psychologist who receives an award on the same night that he is visited by a very unhappy ex-patient. After this encounter, Crowe takes on the task of curing a young boy with the same ills as the ex-patient. This boy “sees dead people”. Crowe spends a lot of time with the boy (Cole) much to the dismay of his wife. Cole’s mom is at her wit’s end with what to do about her son’s increasing problems. Crowe is the boy’s only hope.