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Set in the late 21st century, a subculture of humans have emerged who have been modified genetically by a vampire-like disease, giving them enhanced speed, incredible stamina and acute intelligence, and as they are set apart from “normal” and “healthy” humans, the world is pushed to the brink of worldwide civil war aimed at the destruction of the “diseased” population. In the middle of this crossed-fire is - an infected beautiful woman - Ultraviolet, who finds herself protecting a nine-year-old boy who has been marked for death by the human government as he is believed to be a threat to humans.

Something rotten is brewing beneath the industrial mecca known as Raccoon City. Unknown to its millions of residents, a huge underground bioengineering facility known as The Hive has accidentally unleashed the deadly and mutating T-virus, killing all of its employees. To contain the leak, the governing supercomputer, Red Queen, has sealed all entrances and exits. Now a team of highly-trained super commandos including Rain, Alice and Matt must race to penetrate The Hive in order to isolate the T-virus before it overwhelms humanity. To do so, they must get past the Red Queen’s deadly defenses, face the flesh-eating undead employees, fight killer mutant dogs and battle The Licker, a genetically mutated savage beast whose strength increases with each of its slain victims.