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Eighteen years after their sci-fi adventure show “Galaxy Quest” was canceled, actors Jason Nesmith, Gwen DeMarco, Alexander Dane, Tommy Webber, and Fred Kwan are making appearances at sci-fi conventions and store openings in costume and character. They’re wallowing in despair and at each other’s throats until aliens known as Thermians arrive and, having mistaken the show for fact and consequently modeling their entire culture around it, take them into space to save them from the genocidal General Sarris and his armada.

While being transported in a military ambulance and supposed dead, Eve delivers an offspring and is killed by a half-breed. The baby girl is abducted by Dr. Abbot, and a couple of days later she grows up, reaching adulthood and becoming a gorgeous young woman called Sara. Dr. Abbot expects to develop a perfect DNA using Sara’s eggs and win the Nobel Prize, and invites the student Dean to be his assistant and share his research and future awards. But while Sara unsuccessfully chases a perfect mate for her to generate a perfect being, the flawed half-breeds leaded by Amelia try to reproduce with her to survive their species.